The establishment of collaborative models for use of computing and data resources across various domains all over Europe and worldwide is currently being pursued through several eInfrastructure efforts. In this context, the SEE-GRID regional initiative has recently demonstrated that a geographically-independent, common-pool of computing resources can be of substantial scientific value to a widely distributed, less-resourced region like South-East Europe (SEE). Through the interconnection of the SEE regional infrastructure to the pan-European and worldwide eInfrastructures, the developing SEE sites can benefit from accessing computing power and advanced applications that would otherwise be unfordable, and thus help make real the fundamental objective of minimizing the digital divide in SEE and ensuring equal opportunities for every citizen in the region.